In Memoriam Geoffrey Burnstock: Creator of Purinergic Signaling
نویسندگان
چکیده
منابع مشابه
Purinergic signalling : therapeutic potential * GEOFFREY BURNSTOCK
The concept of a purinergic signalling system, using purine nucleotides and nucleosides as extracellular messengers, was first proposed over 30 years ago. After a brief introduction and update of purinoceptor subtypes, this article focuses on the diverse pathophysiological roles of ATP, ADP, UTP and adenosine. These molecules mediate short-term (acute) signalling functions in neurotransmission,...
متن کاملPurinergic Signaling in Bone
1 Research Center for Ageing and Osteoporosis, Departments of Diagnostics and Medicine, Copenhagen University Hospital Glostrup, 2600 Glostrup, Denmark 2Department of Morphology, Surgery and Experimental Medicine, Section of General Pathology, University of Ferrara, 44121 Ferrara, Italy 3 Bone Biology Laboratory, Department of Cell and Developmental Biology, University College London, London WC...
متن کاملExtracellular purinergic signaling in pancreas.
recognized as important extracellular signaling molecules in many biological systems (1). In epithelia, ATP signaling is thought to regulate fluid transport, and exocrine glands are one of the first epithelia where the effect of ATP on ion channels and Ca signaling was observed (2, 3). Nevertheless, many steps in ATP signaling, also known as purinergic signaling, remain to be clarified. This in...
متن کاملPurinergic signaling in B cells.
Adenosine and adenosine triphosphate are involved in purinergic signaling which plays an important role in control of the immune system. Much data have been obtained regarding impact of purinergic signaling on dendritic cells, macrophages, monocytes and T lymphocytes, however less attention has been paid to purinergic regulation of B cells. This review summarizes present knowledge on ATP- and A...
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The Rockefeller University Press $30.00 J. Gen. Physiol. 2016 Vol. 148 No. 3 207–211 www.jgp.org/cgi/doi/10.1085/jgp.201611676 207 Key physiological functions of organisms, such as sensory transduction, regulation of heart rate, smooth muscle contraction, bile secretion, endocrine regulation, immune responses, and various pathophysiological conditions, including neuropathic pain, diabetes, kidn...
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ژورنال
عنوان ژورنال: Function
سال: 2020
ISSN: 2633-8823
DOI: 10.1093/function/zqaa006